View Answer, 7. She had successfully lost 10 pounds over the last month after the surgery due to mobilization of fat stores to provide acetyl co A and energy. His skin starts to turn blue from lack of oxygen(cyanosis). Tweet . b) 9 c) Squalene 21) A 20- year-old woman has a myocardial infarct and is given an Aspirin to chew. Squalene synthase catalyzes the condensation of two molecules of farnesyl-PP with reduction by NADPH to make squalene. In cholesterol synthesis, six molecules of isopentenyl phosphate condense to form squalene, which is converted to lanosterol and then to cholesterol by a series of enzymatic reactions. She is diagnosed with acute cholecystitis (inflammation of the gall bladder).The gall stones can obstruct the gall bladder, leading to an inadequate concentration of bile salts in the intestine. a) Sterol nucleus with two alkyl chain attached to the ring D of cholesterol SOURCES OF CHOLESTEROL 12/14/13 Biochemistry for medics Cholesterol is derived from diet de novo synthesis and from the hydrolysis of cholesteryl esters. Prednisolone and prednisone are chemically ___________ Which is the first intermediate in cholesterol synthesis? b) Testosterone He is diagnosed with Respiratory distress syndrome due to deficiency of lung surfactant. Analysis of intermediate metabolites in cholesterol biosynthesis suggests that the first oxidative step in cholesterol biosynthesis catalyzed by squalene monooxygenase (SQLE), an important regulator downstream HMG-CoA reductase in cholesterol synthesis, is reduced by degradation of SQLE upon elevation of cellular plasmalogen level. 17) In Abetalipoproteinemia (a rare disease), lipoproteins containing apo B are not formed and lipid droplets accumulate in the intestine and liver. b) Nuclear membrane a) Progesterone Which of the following glycolytic intermediates can be used for the synthesis of glycerol-3-P? a) 8 c) 10 d) Plasma membrane c) Lanosterol. For the production of 1 mole of cholesterol, 18 moles of Acetyl coA, 36 moles of ATP and 16 moles of NADPH are required. When Stearic acid is oxidized, how many Acetyl co A are produced? 1-d) Thyroid hormone synthesis 2-a) Phosphatidyl choline 3-c) Triacylglycerol 4-d) Cholesterol 5-a) Linolenic acid 6-a) Cholesterol 7-c) Cardiolipin 8- b) Lipoprotein lipase 9-c) Impairment of uptake of cholesterol by tissue 10­-d) Acyl CoA View Answer, 4. Which of the following is the major point of regulation on the pathway to cholesterol? 15) A 45 -year-old female presents with pain in the right hypochondrium radiating towards shoulder and back. Definition. Glycerol -3-P can still be produced in the adipose tissue through interconversion of one of the glycolytic intermediate. b) Glycerol derivatives a) 2 b) 3 c) 5 d) 6 View Answer. All the carbon atoms in the cholesterol is provided by acetate. View Answer, 9. View Answer, 10. Which of the following molecular complexes in the blood carries the palmitate residue from the lumen of the gut to the surface of the gut epithelial cell? Learn vocabulary, terms, and more with flashcards, games, and other study tools. c) HMG co-A reductase 1. d) Pyruvate kinase Cholesterol synthesis, also called cholesterologenesis, is a multistep enzymatic biosynthetic process that begins with acetyl-coenzyme A. c) Cytoplasm How many carbons are present in HMG co-A? (3) Condensation of six isoprenoid units to form squalene. The infant is diagnosed with medium chain acyl co A dehydrogenase deficiency. View Answer, 3. d) Sterol nucleus but lack the alkyl chain attached to the ring D of cholesterol How many carbons are present in geranyl pyrophosphate? a) Squalene and Lanosterol are examples of primary bile salts, b) Bile salts are required for transportation of lipids from intestine to liver, c) 95% of the bile salts are excreted in the feces per day, d) They are required for digestion and absorption of lipids. Acetyl CoA Metabolic Biochemistry > MCQ Lipid Synthesis > Flashcards Flashcards in MCQ Lipid Synthesis Deck (14) Loading flashcards ... A thioester derivative of D-β-hydroxybutyrate is an intermediate in the synthetic path, ... Cholesterol is synthesized from: A) acetyl-CoA. d) 6 Multiple Choice Questions (MCQ) in Lipids, Fats & Wax with Detailed Answer Key. b) Isoprene Squalene 10 carbon intermediate 15 carbon intermediate 3)  A molecule of Palmitic acid attached to carbon 1 of glycerol moiety of a triacylglycerol is ingested and digested. a) Mevalonate. The major regulatory enzyme is HMG-CoA reductase. a) Steroids d) Desmosterol. Data suggested that lanosterol, the first intermediate in the pathway that is cyclic instead of linear, was the key regulator, but the researchers knew that a slightly modified version of lanosterol might be …

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